A new, accurate, precise, linear, reproducible and economical spectrophotometric method has been developed and validated for the determination of eletriptan hydrobromide (EH) in bulk drugs and pharmaceutical dosage form. UV Spectrophotometric method is based on measurement of absorption. The absorbance of eletriptan hydrobromide was found to be at 221 and 272 nm maximum wavelengths. Beer-Lambert’s law is obeyed in the concentration range of 2-10 μg/ml and is described by the regression equation y = 0.081x with a regression coefficient (r2) = 0.999. The value of molar absorptivity and Sandell’s sensitivity for EH estimated are 3.098 x 103 L/mol/cm and 0.123 μg/cm2, respectively. Whereas LOD and LOQ were found to be 0.619 and 1.877 μg/ml, respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision, percentage recovery and specificity. The developed method was validated according to ICH guidelines where the developed method was found to be accurate and precise. The proposed method can be successfully applied for the estimation of EH in bulk and pharmaceutical dosage form.
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